N-Desmethyl imatinib [CAS 404844-02-6]
N-Desmethyl imatinib [CAS 404844-02-6]
SKU:QM-0161542-01
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Product Details
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Description
N-Desmethyl imatinib (Norimatinib) is a c-Abl tyrosine kinase inhibitor. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways, and inhibits c-Abl-related neurodegenerative activity and neuroinflammation in vitro. N-Desmethyl imatinib can be used to study neurodegenerative diseases (such as Parkinson's disease) [1][2][3].
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CAS Number
[404844-02-6]
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Molecular Formula
C28H29N7O
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Molecular Weight
479.59
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Smiles
O=C(NC1=CC=C(C)C(NC2=NC(C3=CC=CN=C3)=CC=N2)=C1)C4=CC=C(CN5CCNCC5)C=C4
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Target
Drug Metabolite
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Purity
99.77
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H341, H351, H360, H362
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Precautions
H341, H351, H360, H362
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N-Desmethyl imatinib [CAS 404844-02-6]
N-Desmethyl imatinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.