N-Desmethylclozapine-d8 [CAS 1189888-77-4]
N-Desmethylclozapine-d8 [CAS 1189888-77-4]
SKU:QM-0096118
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Product Details
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Description
N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].
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CAS Number
[1189888-77-4]
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Molecular Formula
C17H9D8ClN4
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Molecular Weight
320.85
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Smiles
ClC1=CC=C2NC3=CC=CC=C3C(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=NC2=C1
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Target
Drug Metabolite; mAChR; Opioid Receptor; Virus Protease
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Isoform
MAChR1; δ Opioid Receptor/DOR
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Solubility
10 mM in DMSO
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Hazard Statement
H301
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Precautions
H301
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N-Desmethylclozapine-d8 [CAS 1189888-77-4]
N-Desmethylclozapine-d8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.