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N-Desmethyltamoxifen [CAS 31750-48-8]
N-Desmethyltamoxifen [CAS 31750-48-8]
SKU:QM-0061192
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Product Details
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Description
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
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CAS Number
[31750-48-8]
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Molecular Formula
C25H27NO
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Molecular Weight
357.5
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Smiles
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=CC=C3
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Target
Drug Metabolite; Endogenous Metabolite; Estrogen Receptor/ERR; PKC
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Isoform
PKC
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H350-H360-H372
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Precautions
P260-P264-P270-P280-P330-P405-P501
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N-Desmethyltamoxifen [CAS 31750-48-8]
N-Desmethyltamoxifen is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.