N-Hydroxyphthalimide [CAS 524-38-9]
N-Hydroxyphthalimide [CAS 524-38-9]
SKU:QM-0186145-01
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Product Details
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Description
N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473) . N-Hydroxyphthalimide has anticancer effects against breast and colon cancer[1][2][3].
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CAS Number
[524-38-9]
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Molecular Formula
C8H5NO3
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Molecular Weight
163.13
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Smiles
O=C1C2=C(C(N1O)=O)C=CC=C2
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Target
Akt; Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; mTOR; Survivin
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Isoform
Bcl-xL; Caspase 3; Caspase 9
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Purity
99.89
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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N-Hydroxyphthalimide [CAS 524-38-9]
N-Hydroxyphthalimide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.