NAE-IN-3 [CAS 951950-33-7]

NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC50 = 0.8 μM) . NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research[1].

[951950-33-7]

C17H18N4O6

374.35

O=C(CNC(CNC(COC1=CC2=C(N=C3N(CCC3)C2=O)C=C1)=O)=O)O

NEDD8-activating Enzyme

Room temperature