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NAMPT degrader-1 [CAS 3011778-39-2]
NAMPT degrader-1 [CAS 3011778-39-2]
SKU:QM-0067463
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Product Details
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Description
NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].
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CAS Number
[3011778-39-2]
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Molecular Formula
C56H68ClN9O5S2
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Molecular Weight
1046.78
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Smiles
O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7
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Target
ATTECs; Autophagy; NAMPT
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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NAMPT degrader-1 [CAS 3011778-39-2]
NAMPT degrader-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.