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Nampt degrader-2 [CAS 3035008-40-0]

Nampt degrader-2 [CAS 3035008-40-0]

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QM-0150760-01

£803.30 GBP
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Product Details

  • Description

    Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS) . Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities[1].

  • CAS Number

    [3035008-40-0]

  • Molecular Formula

    C59H73N9O7S

  • Molecular Weight

    1052.33

  • Smiles

    O=C(C(C1=CC=C(C=C1)C(NCC2=CN=CC=C2)=O)=NC3=C4C=C(C=C3)NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)N4CCC

  • Target

    NAMPT; PROTACs

  • Isoform

    Von Hippel-Lindau (VHL)

  • Purity

    99.41

  • Solubility

    DMSO : 100 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature
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Variant Variant total Quantity Price Variant total
5 mgQM-0150760-01
5 mgQM-0150760-01
£803.30/ea		 £0.00
£803.30/ea £0.00
10 mgQM-0150760-02
10 mgQM-0150760-02
£1,255.28/ea		 £0.00
£1,255.28/ea £0.00
25 mgQM-0150760-03
25 mgQM-0150760-03
£2,435.05/ea		 £0.00
£2,435.05/ea £0.00
50 mgQM-0150760-04
50 mgQM-0150760-04
£3,753.32/ea		 £0.00
£3,753.32/ea £0.00
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Nampt degrader-2 [CAS 3035008-40-0]

Nampt degrader-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.