β-Naphthoflavone-CH2-OH [CAS 2752755-32-9]
β-Naphthoflavone-CH2-OH [CAS 2752755-32-9]
SKU:QM-0061403
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Product Details
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Description
β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].
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CAS Number
[2752755-32-9]
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Molecular Formula
C20H14O3
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Molecular Weight
302.32
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Smiles
O=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
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Target
E3 Ligase Ligand-Linker Conjugates
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Isoform
IAP
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H315-H319-H320
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Precautions
P264-P280-P302+P352-P305+P351+P338-P362
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β-Naphthoflavone-CH2-OH [CAS 2752755-32-9]
β-Naphthoflavone-CH2-OH is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.