Narchinol B [CAS 1356822-09-7]

Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α) . Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC50=2.43 μM) [1].

[1356822-09-7]

C12H16O3

208.25

C[C@@]([C@@H](C1)C)([C@@H](C=C2)O)C(C2=O)=C[C@H]1O

Others

10 mM in DMSO

Room temperature