Nav1.7-IN-13 [CAS 2776235-57-3]

Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine -induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity[1].

[2776235-57-3]

C23H22BrNO5

472.33

C/C(C)=C/CN1C2=CC(Br)=CC=C2[C@@]([C@]3(C(OC)=O)OC(C=CC=C4)=C4C3)(O)C1=O

Sodium Channel

Nav1.7

10 mM in DMSO

Room temperature