Nav1.7-IN-19 [CAS 3097995-73-5]

Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC50 of 0.49 μM. Nav1.7-IN-19 shows high selectivity for Nav1.7, with selectivities of 312-fold and 662-fold against Nav1.1 and Nav1.5 in the inactivated state. Nav1.7-IN-19 exhibits weak inhibition on hERG potassium channels. Nav1.7-IN-19 exhibits analgesic effect and can be used for the research of neurological disease[1].

[3097995-73-5]

C23H23BrClFN4O5S

601.87

NC(C(C1CC1)NCCCC2=C(C=CC(Cl)=C2)OC3=C(C=C(C(F)=C3)S(=O)(NC4=NOC=C4)=O)Br)=O

Potassium Channel; Sodium Channel

Nav1.7

Room temperature