NB-3

NB-3 is a nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 inhibitor. NB-3 intercepts NAD hydrolysis and undergoes covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR) . The resulting small-molecule ADPR adducts are highly potent and confer compelling neuroprotection in neurological injury[1].

C11H14F3N3O

261.24

O=C(NCC(F)(F)F)N(C)[C@H](C1=CC=NC=C1)C

Toll-like Receptor (TLR)

Room temperature