NBI-31772 (hydrate)

NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs) . NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes) . Anxiolytic and antidepressant-like effects[1][2][3].

C17H11NO7.7/4H2O

372.82

O=C(C1=CC(O)=C(O)C=C1)C2=NC(C(O)=O)=CC3=C2C=C(O)C(O)=C3.O

IGF-1R

99.42

DMSO : 100 mg/mL (ultrasonic)

4°C (Powder, stored under nitrogen)

Room Temperature