NC1153 [CAS 150661-91-9]

NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity[1].

[150661-91-9]

C18H38Cl2N2O

369.41

O=C1C(CN(C)C)CCCCCCCCCC1CN(C)C.Cl.Cl

Endogenous Metabolite

Room temperature