NCAO [CAS 20584-81-0]

N-ω-chloroacetyl-L-ornithine (NCAO) is a potent reversible competitive ornithine decarboxylase (ODC) inhibitor that exerts cytotoxic and antiproliferative effects on tumor cell lines with EC50 values ranging from 1 to 50.6 µM. NCAO induces tumor cell Apoptosis and inhibits tumor cell migration in vitro. NCAO also exhibits a potent antitumor activity against both solid and ascitic tumors in a mouse model using the myeloma (Ag8) cell line. NCAO is promising for research of antitumor agents[1].

[20584-81-0]

C7H13ClN2O3

208.64

OC([C@@H](N)CCCNC(CCl)=O)=O

Apoptosis

98.07

H2O : ≥ 100 mg/mL

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