Nedisertib (GMP) [CAS 1637542-33-6]
Nedisertib (GMP) [CAS 1637542-33-6]
SKU:QM-0002445
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Product Details
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Description
Nedisertib (GMP) (Peposertib (GMP) ) is Nedisertib produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Nedisertib is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity[1][2][3].
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CAS Number
[1637542-33-6]
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Molecular Formula
C24H21ClFN5O3
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Molecular Weight
481.91
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Smiles
FC1=CC(Cl)=C([C@@H](C2=CC=C(N=N2)OC)O)C=C1C3=NC=NC4=C3C=CC(N5CCOCC5)=C4
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Target
BCRP; DNA-PK
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Shipping Conditions
Room temperature
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Nedisertib (GMP) [CAS 1637542-33-6]
Nedisertib (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.