NEK7 degrader-1 [CAS 3069891-91-1]

NEK7 degrader-1 (Compound 17) is a NEK7 degrader with a DC50 of 0.1 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].

[3069891-91-1]

C21H22Cl2N4O3

449.33

O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C)C=N3)=O)C=C2Cl)Cl)=O

Caspase; Interleukin Related; NEKs; NOD-like Receptor (NLR)

Caspase 1; IL-1; NEK7; NLRP3

99.79

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice