Nemorubicin (GMP) [CAS 108852-90-0]
Nemorubicin (GMP) [CAS 108852-90-0]
SKU:QM-0073054
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Product Details
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Description
Nemorubicin (Methoxymorpholinyl doxorubicin) GMP is a GMP-class Nemorubicin. Nemorubicin is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity[1][2][3][4].
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CAS Number
[108852-90-0]
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Molecular Formula
C32H37NO13
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Molecular Weight
643.64
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Smiles
COC1=C2C(C(C3=C(O)C(C[C@](C(CO)=O)(O)C[C@]4([H])O[C@H]5C[C@H](N6CCO[C@H](OC)C6)[C@H](O)[C@H](C)O5)=C4C(O)=C3C2=O)=O)=CC=C1
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Target
G-quadruplex
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Nemorubicin (GMP) [CAS 108852-90-0]
Nemorubicin (GMP) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.