Neuropeptide W-30 (rat) [CAS 383415-90-5]

Neuropeptide W-30 (rat) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (rat) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. NPW-30 activates and binds to both GPR7 and GPR8 at similar effective doses[1][2][3].

[383415-90-5]

C165H249N49O38S

3559.11

O=C([C@H]1N(CCC1)C([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC(CNC([C@H](CCSC)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](CO)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)CC5=CC=C(C=C5)O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)CC7=CC=C(C=C7)O)=O)CC8=CN=CN8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O

Neuropeptide B/W Receptor

10 mM in DMSO

Room temperature