NF-κB-IN-4

NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated NF-κB pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research[1].

C18H15FN4O

322.34

COC1=CC(C2=C3CCC4=C(C3=NC(N)=N2)C=C(C=C4)F)=CN=C1

Apoptosis; NF-κB

10mM

98.51

DMSO : 100 mg/mL (ultrasonic; warming; heat to 150°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature