NF (N-Me) GA (N-Me) IL [CAS 409085-42-3]

NF (N-Me) GA (N-Me) IL is a biological active peptide. (This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.)

[409085-42-3]

C32H51N7O8

661.79

O=C([C@@H](N)CC(N)=O)N[C@H](C(N(CC(N[C@H](C(N([C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](CC)C)C)=O)C)=O)C)=O)CC1=CC=CC=C1

Others

10 mM in DMSO

Room temperature