NF449 (octasodium) [CAS 627034-85-9]

NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs[1][2].

[627034-85-9]

C41H24N6Na8O29S8

1505.09

O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2S(=O)(O[Na])=O)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3S(=O)(O[Na])=O)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5S(=O)(O[Na])=O)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6S(=O)(O[Na])=O)=O)=C4

P2X Receptor

P2X1 Receptor

99

H2O : 10 mg/mL (ultrasonic; warming) |DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C (Powder, stored under nitrogen)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335