NIC-0102 [CAS 2806031-94-5]

NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS) -induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β[1].

[2806031-94-5]

C21H25BF2N2O4

418.24

CC(C[C@@H](B(O)O)NC([C@@H](NC(C1=C(C=CC=C1F)F)=O)CC2=CC=CC=C2)=O)C

NOD-like Receptor (NLR) ; Proteasome

98.72

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature