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Nivocasan [CAS 908253-63-4]
Nivocasan [CAS 908253-63-4]
SKU:QM-0008049
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Product Details
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Description
Nivocasan (GS 9450; LB-84451) is a pan-caspase inhibitor that irreversibly arrests caspase-1 activity and inhibits that of caspase-8. Nivocasan inhibits IL-1β cleavage and blocks osteoclast differentiation. Nivocasan inhibits the protein expression of NFATc1 and CSTK[1].
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CAS Number
[908253-63-4]
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Molecular Formula
C21H22FN3O5
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Molecular Weight
415.41
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Smiles
FC[C@@](O)(OC(C1)=O)[C@H]1NC([C@@]2(CC(C3=NC=CC4=C3C=CC=C4)=NO2)C(C)C)=O
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Target
Caspase; Interleukin Related
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Isoform
Caspase 1; Caspase 8; IL-1
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Shipping Conditions
Room temperature
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Nivocasan [CAS 908253-63-4]
Nivocasan is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.