NLRP3-IN-34 [CAS 1392502-55-4]

NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC50 is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis[1].

[1392502-55-4]

C26H22O6

430.45

CC1=COC2=C1C(C(C3=C2C=CC4=C3C(CCC4(C)C)OC(C5=C(C=CC=C5)O)=O)=O)=O

NOD-like Receptor (NLR)

10 mM in DMSO

Room temperature