NLRP3-IN-45

NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC50=41.79 nM) . NLRP3-IN-45 exerts its effects without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model[1].

C27H30FNO6

483.53

O[C@@]12[C@@H](O)[C@]3([H])C(C)(C)CC=C[C@@]3(CO2)[C@@]4([H])[C@]1(C5=O)[C@H](OC(NC6=CC=C(F)C=C6)=O)[C@H](C5=C)CC4

NOD-like Receptor (NLR)

NLRP3

Room temperature