NLRP3-IN-49

NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC50=0.26 μM in THP-1 cells, IC50=0.21 μM in mouse bone marrow macrophages) . NLRP3-IN-49 can directly bind to NLRP3 protein (Kd=1.05 μM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease[1].

C22H23BrN2O4S

491.4

BrC1=CC=C(C=C1)/C=C(C(NCCC2=C(C=CC=C2)OC)=O)\CS(CCC#N)(=O)=O

NOD-like Receptor (NLR)

Room temperature