NLRP3-IN-60

NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits pyroptosis with an IC50 of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1β release with an IC50 of 225 nM in human whole blood[1].

C23H24F2N4O4S

490.52

FC1=NN2C=C1S(=O)(NC(CC3=C(C4=CC(OCC2(C)C)=NC=C4)C=CC(F)=C3C(C)C)=O)=O

NOD-like Receptor (NLR) ; Pyroptosis

Room temperature