NLRP3-IN-74

NLRP3-IN-74 (Compound 11) is an orally active NLRP3 inhibitor with an IC50 value of 2.7 μM. NLRP3-IN-74 can inhibit the release of IL-1β, reducing the release level by approximately 90%, and does not inhibit the release of TNFα. NLRP3-IN-74 can be used in the research of related diseases such as atherosclerosis and Parkinson's disease[1].

C20H22N4O4

382.41

O=C(N1C2CCN(C([C@@H](C)NC(C3=CC=CO3)=O)=O)CC2)NC4=C1C=CC=C4

NOD-like Receptor (NLR)

NLRP3

Room temperature