NLRP3-IN-75

NLRP3-IN-75 is an orally active NLRP3 inhibitor. NLRP3-IN-75 suppresses IL-1β secretion (IC50 = 23 nM) . NLRP3-IN-75 selectively inhibits NLRP3 activation by disrupting inflammasome assembly without affecting NLRC4 or AIM2 inflammasomes. NLRP3-IN-75 exhibits superior efficacy in acute peritonitis, diabetic kidney disease and IBD models[1].

C20H30N4O3S

406.54

O=C(NC1=C2CCCC2=CC3=C1CCC3)NS(N(C4CCN(CC4)C)C)(=O)=O

Interleukin Related; NF-κB; NOD-like Receptor (NLR)

IL-1

Room temperature