NLRP3-IN-8 [CAS 2768650-56-0]

NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC50 value of 1.23 μM against IL-1 β. NLRP3-IN-8 has good metabolic stability to liver microsomes (t1/2 = 138.63 min), and has almost no toxicity (against L02: IC50 > 100 μM) [1].

[2768650-56-0]

C23H20N2O6

420.41

COC1=CC(OC)=C(C(/C=C/C2=CC=C(C=C2)NC(C3=CC=CO3)=O)=C1)/C=C/[N+]([O-])=O

NOD-like Receptor (NLR)

NLRP3

10 mM in DMSO

Room temperature