NLRP3/URAT1-IN-1 [CAS 2994637-53-3]

NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 (IC50 = 3.81 μM). NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC50 of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia[1].

[2994637-53-3]

C24H17BrN2O3S2

525.44

O=C(C(N1CC2=C3C=CC=CC3=C(Br)C=C2)=CC4=C1C=CC=C4)NS(=O)(C5=CC=CS5)=O

GLUT; Interleukin Related; NOD-like Receptor (NLR) ; OAT; URAT1

IL-1; NLRP3

Room temperature