NM-002

NM-002 is a metabolite of prodrug NM-001 , with NIR emission. NM-002 generates through activates the prodrug NM-001 by overexpressed Cathepsin B (CTSB) within tumor cells. NM-002 has no toxicity towards tumor cells and can escape from the lysosomes into the cytoplasm. NM-002 can be used for real-time drug release monitoring research[1].

C65H81ClN14O16

1349.88

OC1=CC=C(C[C@@H](NC([C@@H](NC2=O)CC(O)=O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NC2)=O)=O)CCCCNC(CCC3=CN(CCOCCOCCOCCOC4=CC(OC(/C=C/C5=CC(Cl)=C(O)C(CO)=C5)=C/C6=C(C#N)/C#N)=C6C=C4C(C)(C)C)N=N3)=O)=O)C=C1

Drug Metabolite

Room temperature