NN1177 (TFA)

NN1177 (NNC9204-1177) TFA is a long-acting GLP-1/glucagon receptor co-agonist. NN1177 TFA can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice[1][2].

C206H323N51O66.xC2HF3O2

O=C(NC(C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@@H](C)O)=O)CCCCNC(CC[C@H](NC(CC[C@@H](C(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CC[C@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)C(O)=O)=O)CO)=O)CCC(O)=O)=O)CO)=O)=O)C(O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC1=CNC2=CC=CC=C12)=O)CCC(N)=O)=O)C(C)C)=O)CC3=CC=CC=C3)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)CCC(O)=O)=O)CC(C)C)=O)CC4=CC=C(O)C=C4)=O)CCCCN)=O)CO)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)[C@@H](C)O)=O)CC5=CC=CC=C5)=O)[C@@H](C)O)=O)=O)CCC(N)=O)=O)(C)C)[C@@H](N)CC6=CNC=N6.OC(C(F)(F)F)=O.[x]

Cytochrome P450; GCGR; GLP Receptor

CYP3A4

98.66

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Blue Ice