NNRT-IN-12

NNRT-IN-12 (compound 19) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor with an IC50 value of 0.107 μM for WT HIV-1 RT. NNRT-IN-12 shows anti-HIV-1 activity with EC50 value of 14.1, 5.03, 7.64, 27.1 nM for L100I, K103N, Y181C, Y188L mutant HIV-1 strains, respectively. NNRT-IN-12 shows cytotoxicity[1].

C30H28F2N6O2S

574.64

O=C(N)C1=CC=C(CN2CC(F)(F)C(NC3=NC(OC4=C(C)C=C(/C=C/C#N)C=C4C)=C5C(C=CS5)=N3)CC2)C=C1

HIV; Reverse Transcriptase

HIV-1

Room temperature