NO-IN-1

NO-IN-1 (Compound 7a) inhibits the production of NO (IC50 = 3.13 μΜ) . NO-IN-1 has anti-inflammatory effects. NO-IN-1 downregulates the expression of COX-2 and iNOS by inhibiting the NF-κB signaling pathway[1].

C33H40N4O5

572.69

O=C(OCC1=CN(CCN2C(C(C3=C2C=CC=C3)=O)=O)N=N1)C/C(C=O)=C\C[C@H]4C(CC[C@@]5([H])C(C)(C)CCC[C@]45C)=C

COX; NF-κB; NO Synthase

Room temperature