NODAGA-NHS [CAS 1407166-70-4]

NODAGA-NHS (NODA-GA-NHS ester) is a [64]Cu chelator and the dissociated form of DOTA-trastuzumab in vivo. NODAGA-NHS was added in 0.1 M borate buffer at a ratio of 5/20/100 and was able to effectively bind trastuzumab (10 mg/mL) (4°C, 20 h) . The copper content of the [64]Cu-NODAGA-trastuzumab was up to 80%. After blood was drawn from the caudal vein of mice, [64]Cu-NODAGA-trastuzumab was injected and showed good tumor uptake in mice expressing HER2 tumors, showing good PET imaging tracking ability.

[1407166-70-4]

C19H28N4O10

472.45

OC(C(N(CCN1CC(O)=O)CCN(CC1)CC(O)=O)CCC(ON(C2=O)C(CC2)=O)=O)=O

EGFR; Radionuclide-Drug Conjugates (RDCs)

RDC Bifunctional Chelator

Room temperature

H302-H315-H319

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501