Nonapeptide-1 [CAS 158563-45-2]

Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM) . Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively) . Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].

[158563-45-2]

C61H87N15O9S

1206.5

O=C(N1[C@@H](CCC1)C(N[C@H](C(N)=O)C(C)C)=O)[C@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CC3=CC=CC=C3)NC([C@H]4N(CCC4)C([C@@H](N)CCSC)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O

Melanocortin Receptor

MC1R; MC3R; MC4R; MC5R

99.04

H2O : 44.44 mg/mL (adjust pH to 2 with 1 M HCl)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Blue Ice

H302

H302