NOX4-IN-1

NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F[1].

C26H16ClN3O3

453.88

CN1C2=C(C=C(C3=C(Cl)C=C(OC(NC(C4=CC=CC(C#N)=C4)=O)=CC5=O)C5=C3)C=C2)C=C1

NADPH Oxidase; Reactive Oxygen Species (ROS) ; TGF-beta/Smad

Room temperature