NOX5-IN-2

NOX5-IN-2 (Compound 17) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC50s of 0.70 μM. NOX5-IN-2 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC50: 1.8 μM) . NOX5-IN-2 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation[1].

C18H11ClN6OS

394.84

ClC1=CC=C2N=C(OC2=C1)SC3=C4C(N(N=N4)CC5=CC=CC=C5)=NC=N3

NADPH Oxidase; Reactive Oxygen Species (ROS)

DUOX1; NOX1; NOX2; NOX4; NOX5

Room temperature