NoxA1ds (TFA)

NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM) . NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors[1].

C50H88N14O15.xC2HF3O2

OC(C(F)(F)F)=O.CC(C)[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H]1N(CCC1)C([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

NADPH Oxidase

NOX1

10 mM in DMSO

Room temperature