NP3-562 [CAS 2409825-32-5]

NP3-562 is an orally active NLRP3 Inhibitor. NP3-562 inhibits IL-1β release in the supernatant of Nigericin -stimulated THP-1 cells (IC50 = 66 nM), human whole blood (IC50 = 214 nM) and a mouse acute peritonitis model. NP3-562 can be used for the study of acute peritonitis[1].

[2409825-32-5]

C19H24ClN5O3S

437.94

CC(O)(C(N1C2=C(SC(Cl)=C2)C=C13)=NN(CC(N[C@H]4CN(CCC4)C)=O)C3=O)C

Interleukin Related; NOD-like Receptor (NLR)

IL-1; NLRP3

98.16

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature