NPD10084 [CAS 1040706-91-9]

NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1].

[1040706-91-9]

C21H19N3O2

345.39

COC1=CC=CC2=C1C=C(C(N3CCC4=C(C5=CC=CC=C5N4)C3)=O)N2

Pyruvate Kinase

99.69

DMSO : ≥ 100 mg/mL

-20°C, 3 years (Powder)

Blue Ice

H315, H319, H320

H315, H319, H320