NR-11c

NR-11c is a selective and potent p38α PROTAC degrader. NR-11c effectively degrades p38α in a variety of tumor cells. When administered intraperitoneally or intravenously to mice, NR-11c primarily acts in the liver. NR-11c can be used in cancer research. (Pink: p38α inhibitor 5 ; Black: linker (HY-159800) ; Blue: VHL E3 ligase ligand (HY-112078) ).

C59H71BrF2N10O8S

1198.22

O=C([C@H]1N(C([C@@H](NC(CCCCCNC(CCCN2N=NC(CCCNC(C3=CC=C(C)C(N4C(C)=CC(OCC5=CC=C(F)C=C5F)=C(Br)C4=O)=C3)=O)=C2)=O)=O)C(C)(C)C)=O)C[C@@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C

P38 MAPK; PROTACs

P38α

99.75

DMSO : ≥ 100 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature