NR-7h [CAS 2550399-06-7]

NR-7h is a potent and selective p38α and p38β degrader with DC50 values of 24 nM and 27.2 nM for p38α in T47D, MB-MDA-231 cells, respectively[1].

[2550399-06-7]

C48H50BrF2N9O8

998.87

O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5

P38 MAPK; PROTACs

96.9

10 mM in DMSO

-20°C, 3 years (Powder)

Blue Ice