NS8593 [CAS 875755-39-8]

NS8593 is an SK channel (small conductance Ca2+-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3) . NS8593 inhibits all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+) . NS8593 does not affect the Ca2+-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively) . NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC50 = 1.6 mM) . NS8593 can be used for the study of central nervous system (CNS) related diseases[1][2].

[875755-39-8]

C17H17N3

263.34

C1(N[C@@H]2CCCC3=C2C=CC=C3)=NC4=CC=CC=C4N1

Potassium Channel; TRP Channel

Room temperature