NSC-658497 [CAS 909197-38-2]

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SKU:QM-0155374-01

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Description
NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation[1].
CAS Number
[909197-38-2]
Molecular Formula
C20H10N2O6S2
Molecular Weight
438.43
Smiles
O=C1/C(C(C2=CC=CC=C2O1)=O)=C\N3C(S/C(C3=O)=C\C4=CC=C([N+]([O-])=O)C=C4)=S
Target
Ras; SOS1
Solubility
10 mM in DMSO
Shipping Conditions
Room temperature

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NSC-658497 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.