NSC 850745

NSC 850745 is a selective and potent c-Met/STAT3 inhibitor with IC50 values of 210 and 670 nM. NSC 850745 can inhibit cell proliferation, induce G2/M phase arrest and induce apoptosis. NSC 850745 can downregulate AKT-1, VEGF and Bcl-2 expression and upregulate p53, Bax and caspase expression. NSC 850745 can be used for the research of cancer, such as leukemia and colon cancer[1].

C24H25N7O

427.5

O=C(CN1CCN(CC1)C2=C3C(N(N=C3)C4=CC=CC=C4)=NC=N2)NCC5=CC=CC=C5

Akt; Apoptosis; Bcl-2 Family; Caspase; c-Met/HGFR; MDM-2/p53; STAT; VEGFR

Akt1; Bcl-2; Caspase 3; Caspase 8; Caspase 9; Met; STAT3

Room temperature