NSD2-PWWP1-IN-5 [CAS 217798-45-3]

NSD2-PWWP1-IN-5 (Compound 13) is an effective NSD2-PWWP1 inhibitor with a Kd value of 78 nM. NSD2-PWWP1-IN-5 competitively blocks the recognition of H3K36me2 and DNA by NSD2-PWWP1, thereby weakening its binding ability to nucleosomes. NSD2-PWWP1-IN-5 inhibits the proliferation of U2OS osteosarcoma cells and induces cell cycle arrest and apoptosis. NSD2-PWWP1-IN-5 can be used for the study of osteosarcoma[1].

[217798-45-3]

C13H10N2OSe

289.19

O=C(N(C1=CC=C(N)C=C1)[Se]2)C3=C2C=CC=C3

Apoptosis; Histone Methyltransferase

Room temperature