NT376 [CAS 2820208-97-5]

NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1].

[2820208-97-5]

C21H20F4N4O2

436.4

O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2F

HDAC

Room temperature